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1st Department Day
On March 6th, 2013 the 1st Department Day of DBS was celebrated with great enthusiasm.
Here is the program schedule for the 1st Department Day
Inter IISER Tropical Biology meeting 2013
Inter Indian Institute of Science Education and Research Tropical Biology meeting, iitb 2013
Date : 25.10.2013 – 27.10.2013
1) Dr. Hema Somanathan (IISER Thiruvananthapuram) : The buzz about Nocturnal bees.
2) Dr. Manjari Jain (IISER Mohali) : Cocktail party problem in a rainforest chorus and how crickets solve it.
3) Dr. Ullasa Kodandaramaiah (IISER Thiruvananthapuram) : Eyespots and sexual parasites in butterflies
Guest Lecture by Dr. Saurabh Chattopadhyay
Title :
Dual Roles of IRF-3 in Antiviral Defense
activates the latent transcription factor IRF-3 causing its nuclear
translocation and the induction of antiviral genes including interferons.
We have identified that HDAC6 is required for the transcriptional activity
of IRF-3. Our results indicate that the HDAC6-mediated effect on the
transcriptional activity of IRF-3 is via deacetylation of β-catenin,
which enables the recruitment of transcriptional co-activators. In
addition to transcription of antiviral genes, IRF-3 activated by
cytoplasmic RIG-I signaling pathway can efficiently trigger cellular
apoptosis. Using appropriate mutants of IRF-3, we demonstrated that the
apoptotic activity was independent of its transcriptional activity.
Apoptosis was triggered by the interaction of IRF-3 with the pro-apoptotic
protein BAX via a BH3-like domain of IRF-3, their co-translocation to the
mitochondria and the resulting activation of the mitochondrial apoptotic
pathway. Selective ablation of IRF-3 functions significantly augmented
virus replication and pathogenesis. The presentation will highlight how
IRF-3 functions in the two distinct pathways and contributes to the
overall host antiviral response Inflatable Pools.
Speaker : Dr. Saurabh Chattopadhyay
Project Staff Scientist,
Dept. of Molecular Genetics,
The Lerner Research Institute,
Cleveland Clinic, Cleveland, Ohio, USA